Investigator Studies Program (MISP): Measles, Mumps, Rubella & Varicella
Effective January 2021, the Measles, Mumps, Rubella & Varicella Investigator Studies Program (MISP) Committee will accept proposals within our current areas of interest (AOI) up to June 5, 2021. This is a competitive process that will be conducted by the Measles, Mumps, Rubella & Varicella MISP in 2021. Decisions will be made on the basis of scientific merit and strategic fit within the AOI. Please review the critical activities and abide by the timelines as outlined below. The program requests that investigators specify how they will support diversity in enrollment to include traditionally underrepresented minorities/ethnic groups.

The following areas are of interest to Investigator Studies Program Committee:
  • Studies on a third dose of measles, mumps, rubella vaccine (M-M-R II™) focused upon:
    • Immunogenicity (humoral and cell-mediated) and safety in a non-outbreak situation, including immunogenicity against mumps
    • Effectiveness, safety, economics, and/or acceptability in an outbreak setting
  • Small scale studies that advance the understanding of mumps immunology and vaccine response with respect to:
    • In vitro correlates of immune protection against mumps disease,
    • Evaluation of effect of circulating mumps genotype on vaccine efficacy/effectiveness
    • Persistence of immunity
  • Studies on persistence of immunity to measles, mumps, rubella and varicella (MMRV) post vaccination, especially in populations with high vaccination rates.
    • Specific consideration should be given to studies evaluating longer term persistence and durability
  • Studies evaluating the burden of illness of varicella in regions, countries or populations in which these data are limited
    • Studies in Asia-Pacific region are of specific interest
    • Studies in Asia-Pacific region are of specific interest
  • Studies evaluating the inappropriate use of antibiotics and subsequent possible contribution to antimicrobial resistance due to treating febrile children with antibiotics for vaccine preventable diseases

Please complete a protocol with detailed budget via Visiontracker, the Company's on-line study management system (in US). The proposals will be collectively reviewed and selected by the Measles, Mumps, Rubella & Varicella MISP Committee.


Critical Activities and Timelines:
Activity 1- Review Cycle
Protocol Submission / Detailed Budget June 5, 2021
Final Comments to Investigator August 11, 2021


MISP Information
This site is intended for US investigators only. Investigators outside of the US interested in submitting research proposals to the Investigator Studies Program should contact their local MSD office.