Investigator Studies Program (MISP): Letermovir
Effective December 2020, the CMV Investigator Studies Program (MISP) Committee will accept proposals within our current areas of interest (AOI) up to April 2, 2021. This is a competitive process that will be conducted by the CMV MISP in 2021. Decisions will be made based on scientific merit and strategic fit within the AOI. Please review the critical activities and abide by the timelines as outlined below. The program requests that investigators specify how they will support diversity in enrollment to include traditionally underrepresented minorities/ethnic groups.

The following areas are of interest to Investigator Studies Program Committee
  • Studies that characterize CMV infection/disease in patient populations at moderate risk for reactivation:
    • D+/R- and D+/R+ adult allogeneic stem cell transplant recipients
    • D+/R+ and D-/R+ adult solid organ transplant recipients
  • Impact of CMV infection/disease in under-represented solid organ transplant populations
    • E.g., but not limited to Black/African Americans, LatinX, Indigenous peoples
  • Studies understanding the burden of CMV disease and relationship to CMV specific cell mediated immunity (CMI) in immunocompromised patient populations outside of allogeneic HCT recipients
  • Studies to optimize CMV specific prophylaxis strategies in immunocompromised patients utilizing CMV specific CMI or other immunologic markers to guide the initiation and the duration of letermovir for CMV prophylaxis
  • Studies that characterize the relationship between induction immunosuppression strategies and the burden of CMV infection/disease with an emphasis on CMV specific CMI in Kidney Transplant recipients
  • Studies that characterize the relationship and clinical impact between maintenance immunosuppression or treatment of acute rejection and CMV infection/disease with an emphasis on CMV specific CMI in Kidney Transplant recipients
Please complete a protocol with detailed budget via Visiontracker, the Company's on-line study management system (in US). The proposals will be collectively reviewed and selected by the CMV MISP Committee.

Critical Activities and Timelines:
Activity 1st Review Cycle
Protocol Submission with Detailed Budget April 2, 2021
MISP-RC Review Meeting May 18, 2021

MISP Information
This site is intended for US investigators only. Investigators outside of the US interested in submitting research proposals to the Investigator Studies Program should contact their local MSD office.