Investigator Studies Program (MISP): Anesthesia
Effective November 2021, the Anesthesia Investigator Studies Program (MISP) Committee will accept proposals within our current areas of interest (AOI) as noted below. This is a competitive process that will be conducted by the Anesthesia MISP in 2022. Decisions will be made on the basis of scientific merit and strategic fit within the AOI. Please review the critical activities and abide by the timelines as outlined below. The program requests that investigators specify how they will support diversity in enrollment to include traditionally underrepresented minorities/ethnic groups.

The following areas are of interest to the Investigator Studies Program Committee:

  • NEUROMUSCULAR BLOCKADE (NMB):
    • Impact of mechanism of reversal (Neo/Antimuscarinic vs Sugammadex) (spontaneous vs Sugammadex) on autonomic dysfunction (Patient Outcomes /impact on healthcare resource utilization):
      • GI:Time to return to bowel function
      • Urinary:Time to postoperative voiding
  • RESIDUAL NMB:
    • Impact of residual NMB on postoperative recovery and/or other perioperative outcomes overall
  • PERI-OPERATIVE PROTOCOLS:
    • Contribution of active neuromuscular relaxant reversal on patient outcomes in specific surgical pathways, in bundled care pathways, or in enhanced recovery protocols.
Specific populations of interest include elderly, or obese patients, those with cardiac conditions or post-COVID-19 infection; and surgeries in the ambulatory surgery setting.

Please complete a protocol with detailed FMV Budget Template via Visiontracker, the Company's on-line study management system (in US). The Protocols will be collectively reviewed and selected by the Anesthesia MISP Committee.

Critical Activities and Timelines:
Activity 1st Review Cycle 2nd Review Cycle 3rd Review Cycle
Protocol Submission with Detailed Budget January 1, 2022 May 1, 2022 September 1, 2022
Final Comments to Investigator February 8, 2022 June 4, 2022 October 8, 2022
Final Protocol Submission by Investigator February 22, 2022 June 18, 2022 October 19, 2022
Final Protocol Approval by Committee March 1, 2022 June 25, 2022 October 29, 2022


MISP Information
This site is intended for US investigators only. Investigators outside of the US interested in submitting research proposals to the Investigator Studies Program should contact their local MSD office.