Investigator Studies Program (MISP): Vaccine Confidence
Effective January 2021, the Merck Investigator Studies Program Review Committee (MISP-RC) for Vaccine Confidence will accept proposals within our current areas of interest (AOI) up to March 26, 2021. This is a competitive review process that will be conducted on April 13, 2021 by the Vaccine Confidence MISP Review Committee. Decisions will be made on the basis of scientific merit and strategic fit within the AOI. Please review the critical activities and abide by the timelines as outlined below. The program requests that investigators specify how they will support diversity in enrollment to include traditionally underrepresented minorities/ethnic groups.

The following areas are of interest to Investigator Studies Program Committee:

Focus Area 1: Resilient Immunization Programs

  • Research on reasons for missed opportunities for vaccination among defined large population cohorts with access to vaccination services, e.g., the impact of national, state, or local-level policies or factors and ethnic, cultural, religious, or other social and demographic factors that may contribute to vaccine refusal or missed vaccination.
  • Research on the contributing factors and attributes of resilient immunization programs and how learnings from the COVID-19 pandemic and other past challenges can help programs be better prepared in the future
  • Research on the role and impact of community-based vaccination programs that are delivered in settings other than the physician’s office.

Focus area 2: Role of Health Care Provider in Building Confidence in Vaccination

  • Research on the effectiveness of novel and routinely used communication techniques in improving vaccine acceptance among hesitant individuals. (note: this shouldn’t be limited to F2F interactions with patients, as HCPs can also reach patients virtually)
  • Research on vaccine hesitancy attitudes, behaviors, and practice tendencies among HCPs, including physicians, nurses, dentists, and other staff.

Focus Area 3: Effective Communications in Building Confidence in Vaccination

  • Research on the role and impact of media, digital platforms, including social media, blogs, other web-based forums, and traditional media (TV, Radio) on vaccination beliefs, attitudes, and uptakes
  • Research on effective messaging and communications approaches to improve health/vaccine literacy and promote vaccine confidence and acceptance in vaccination.

Focus Area 4: Impact of Health/Vaccine Literacy and Disparities in Building Confidence in Vaccination and Acceptance

  • Research on the impact of health/vaccine literacy on building confidence in vaccination
  • Research on the prevalence of and reasons for vaccine hesitancy among at-risk populations and marginalized populations
  • Research evaluating the social and economic impact of missed doses of vaccine resulting from vaccine hesitancy

Please complete a protocol with detailed budget via Visiontracker, the Company's on-line study management system (in US). The proposals will be collectively reviewed and selected by the Vaccine Confidence MISP Committee.


Critical Activities and Timelines:
Deadline Dates/Activity 1st Review Cycle
Protocol Submission with Detailed Budget March 26, 2021
Target Meeting Date April 13, 2021
Target Comments to Investigator June 1, 2021


MISP Information
This site is intended for US investigators only. Investigators outside of the US interested in submitting research proposals to the Investigator Studies Program should contact their local MSD office.