Investigator Studies Program (MISP): Ebola
Effective April 2021, the Merck Investigator Studies Program Review Committee (MISP-RC) for Ebola will accept proposals within our current areas of interest (AOI) up to June 28, 2021. This is a competitive review process that will be conducted by the Ebola MISP Review Committee. Decisions will be made on the basis of scientific merit and strategic fit within the AOI. Please review the critical activities and abide by the timelines as outlined below. The program requests that investigators specify how they will support diversity in enrollment to include traditionally underrepresented minorities/ethnic groups.

The following areas are of interest to Investigator Studies Program Committee:

    Studies involving immunological responses to the vaccine rVSVΔG-ZEBOV-GP should be based on populations vaccinated through previously established clinical trials or outbreak response efforts.Studies on correlates of protection for Ebola, including studies of individuals following natural infection or following vaccination

    Durability of immunogenicity or protection from rVSVΔG-ZEBOV-GP vaccination including populations such as health care providers, pediatrics, pregnant or lactating women, and immunocompromised / HIV+ individuals

    Modeling studies to inform Ebola vaccination strategies and stockpile recommendations Studies to identify methods to improve pharmacovigilance systems in African countries prone to Ebola outbreaks

    Coadministration with other vaccines or products including monoclonal antibodies Safety and immunogenicity after a dose of rVSVΔG-ZEBOV-GP or other Ebola vaccine administered ≥18 months after a prior Ebola vaccination


Please complete a protocol with detailed budget via Visiontracker, the Company's on-line study management system (in US). The proposals will be collectively reviewed and selected by the Ebola MISP Committee.

Critical Activities and Timelines:
Deadline Dates/Activity Review Cycle
Protocol Submission with Detailed Budget June 28, 2021
Target Review Committee Meeting Date August 31, 2021


MISP Information
This site is intended for US investigators only. Investigators outside of the US interested in submitting research proposals to the Investigator Studies Program should contact their local MSD office.