Investigator Studies Program (MISP): Dengue
Effective June 2020, the Investigator Studies Program Review Committee (MISP-RC) will accept proposals within our current areas of interest (AOI) for DENGUE. This is a competitive review process that will be conducted by the DENGUE MISP Review Committee. Decisions will be made on the basis of scientific merit and strategic fit within the AOI. Please review the critical activities and abide by the timelines as outlined below. The program requests that investigators specify how they will support diversity in enrollment to include traditionally underrepresented minorities/ethnic groups.

The following areas are of interest to Investigator Studies Program Committee:

Focus Area 1: Epidemiology

Epidemiologic studies that describe:

  • The burden of dengue infection and disease in specific sub-populations (e.g. Travelers, Older individuals, Individuals with comorbidities or who are immunocompromised, etc.)
  • The burden of dengue infection and disease in under-studied regions of the world (e.g. Africa, South/Central Asia, etc.)
  • Demographic changes in the epidemiology of dengue infection and disease in endemic countries in Asia Pacific and/or Latin America.
Focus area 2: Immunology

  • Laboratory and translational studies to characterize the humoral and cellular immune responses to dengue infection and disease.
  • Translational studies to identify immunologic markers associated with the differential risk of developing dengue illness including severe dengue disease following natural infection.
  • Pilot studies to evaluate novel laboratory assays and clinical measures for diagnosis of dengue illness including severe disease.
Focus Area 3: Modeling

  • Development of mathematical models related to the natural history of dengue infection including:
    • Models that help identify and validate immune correlates related to progression of dengue infection to disease/severe disease
    • Models that help identify and validate immune correlates related to protection against dengue infection, development of symptomatic illness including severe disease
  • Development of mathematical models related to the epidemiology of dengue infection and public health impact of interventions:
    • Predict changes in the intensity and demographic characteristics of the burden of dengue infection and disease in endemic regions.
    • Understand the impact (e.g. cost-effectiveness) of vector control strategies on dengue infection and disease in endemic regions alone or in conjunction with vaccination.
Focus Area 4: Vaccine Confidence

  • Qualitative and quantitative studies to describe barriers to dengue vaccine acceptance and uptake in dengue endemic regions.
  • Pilot studies to evaluate interventions that reduce dengue vaccine hesitancy and increase acceptance in dengue endemic regions.

Please complete a protocol with detailed budget via Visiontracker, the Company's on-line study management system (in US). The proposals will be collectively reviewed and selected by the DENGUE MISP Committee.


Critical Activities and Timelines:
Deadline Dates/Activity Review Cycle
Protocol Submission with Detailed Budget November 20, 2020
Target Review Committee Meeting Date January 2021


MISP Information
This site is intended for US investigators only. Investigators outside of the US interested in submitting research proposals to the Investigator Studies Program should contact their local MSD office.