Investigator Studies Program (MISP): Dengue

Effective February 2023, the Investigator Studies Program Review Committee (MISP-RC) for DENGUE will accept protocols within our current areas of interest (AOI) up to June 12, 2023. This is a competitive review process that will be conducted by the DENGUE MISP Review Committee. Decisions will be made on the basis of scientific merit and strategic fit within the AOI. Please review the critical activities and abide by the timelines as outlined below. The program requests that investigators specify how they will support diversity in enrollment to include traditionally underrepresented minorities/ethnic groups.

The following areas are of interest to Investigator Studies Program Committee:

Focus Area 1: Epidemiology

• The burden of dengue infection and disease in specific sub-populations (e.g., travelers, older individuals, individuals with comorbidities or who are immunocompromised, etc.)
• The burden of dengue infection and disease in under-studied regions of the world (e.g., Africa, South and Central Asia, and others)
• Demographic changes in the epidemiology of dengue infection and disease in endemic countries in Asia Pacific and/or Latin America.
• Impact of large dengue outbreaks or peak dengue cases on the healthcare system (e.g., hospital occupancy, dengue severity compared to non-outbreak periods, lengths of stay for dengue and non-dengue patients, outcomes for dengue and non-dengue patients, postponement of elective surgeries and appointments and amount of revenue lost vs. deferred as a result)
• The burden of dengue infection in pregnancy: maternal and fetal outcome
• Post-acute, persistent, or long-term dengue sequelae in endemic countries

Focus Area 2: Modeling

• Development of mathematical models related to the epidemiology of dengue infection and public health impact of interventions:
• Cost-effectiveness of dengue vaccination vs. the cost of managing dengue disease (outpatient, inpatient, and severe) in endemic countries
• Understand the impact (e.g., cost-effectiveness, sustainability) of vector control strategies on dengue infection and disease in endemic regions alone or in conjunction with vaccination
• Modeling to predict changes in the future incidence of autochthonous dengue infection in non-endemic regions

Focus Area 3: Vaccination Confidence

• Qualitative and quantitative studies to describe barriers to dengue vaccine acceptance and uptake in dengue endemic regions.
• Pilot studies to evaluate interventions that reduce dengue vaccination hesitancy and increase acceptance in dengue endemic regions

Please complete a protocol with detailed budget via Visiontracker, the Company's on-line study management system (in US) or your MSD country representative (outside US). The protocols will be collectively reviewed and selected by the DENGUE MISP Committee.

Critical Activities and Timelines:

Deadline Dates/Activity	Review Cycle
Full Protocol Submission with Detailed Budget	June 12, 2023
Target Final Comments to Investigators	August 10, 2023

MISP Information
This site is intended for US investigators only. Investigators outside of the US interested in submitting research proposals to the Investigator Studies Program should contact their local MSD office.