Investigator Studies Program (MISP): Measles, Mumps, Rubella & Varicella
Effective January 2019, the Measles, Mumps, Rubella & Varicella Investigator Studies Program (MISP) Committee will accept proposals within our current areas of interest (AOI) up to April 5, 2019. This is a competitive process that will be conducted by the Measles, Mumps, Rubella & Varicella MISP in 2019. Decisions will be made on the basis of scientific merit and strategic fit within the AOI. Please review the critical activities and abide by the timelines as outlined below.

The following areas are of interest to Investigator Studies Program Committee:
  • Studies on a third dose of measles, mumps, rubella vaccine (M-M-RTMII) focused upon:
    • Immunogenicity (humoral and cell-mediated) and safety in a non-outbreak situation, including immunogenicity against mumps
    • Effectiveness, safety, economics, and/or acceptability in an outbreak setting
  • Small scale studies that advance the understanding of mumps immunology and vaccine response with respect to:
    • In vitro correlates of immune protection against mumps disease,
    • Evaluation of effect of circulating mumps genotype on vaccine efficacy/effectiveness
    • Persistence of immunity
  • Studies of persistence of immunity to measles, mumps, rubella and varicella, especially in populations with high vaccination rates.
  • Studies evaluating the burden of illness of varicella in regions, countries or populations in which these data are limited.

Please complete a full protocol and detailed budget via Visiontracker, the Company's on-line study management system (in US) or your MSD country representative (outside US). The proposals will be collectively reviewed and selected by the Measles, Mumps, Rubella & Varicella MISP Committee.


Critical Activities and Timelines:
Activity 1- Review Cycle
Full Protocol Submission / Detailed Budget April 5, 2019
Final Comments to Investigator June 14, 2019


MISP Information
This site is intended for US investigators only. Investigators outside of the US interested in submitting research proposals to the Investigator Studies Program should contact their local MSD office.