Investigator Studies Program (MISP): Cough
Effective November 2018, the Cough Investigator Studies Program (MISP) Committee will accept proposals within our current areas of interest on a rolling basis. Reviews will occur monthly in 2019. This is a competitive process that will be conducted by the Cough MISP in 2019. Decisions will be made based on scientific merit and strategic fit within the AOI. Please review the critical activities and abide by the timelines as outlined below.

The following areas are of interest to Investigator Studies Program Committee:
  • Observational cohort studies of refractory chronic cough (RCC) or unexplained chronic cough (UCC) populations to describe:
    • Patient characteristics (age, gender, race, ethnicity) and/or methods to identify RCC or UCC patients in large databases
    • Burden of illness: social, psychological, physical and quality of life impact on RCC or UCC patients and their immediate surrounding environment (spouse, friends, relative colleagues)
    • Health care resource utilization, treatments and health care costs
      • Prior to being diagnosed with RCC or UCC
      • After diagnosis of RCC or UCC
    • Indirect costs of chronic cough, including productivity losses
  • Observational or database studies of the diagnostics and treatment evaluations needed to diagnose RCC and UCC in different settings (specialized cough clinics, second line respiratory outpatient clinics and primary care). This work would further our understanding of:
    • Current diagnostic practice for RCC or UCC Variability in diagnostic work-up between different specialties (GPs, Allergists, Pulmonologists, specialized Cough Clinics) and/or different countries (USA, UK, other)
    • Amount of time that elapse between evaluation of CC and RCC or UCC diagnosis
    • Different patterns of workup that suggest opportunities to facilitate RCC and UCC diagnoses
  • Surveys to evaluate patient experiences or preferences related to RCC or UCC diagnosis, treatment or impact on daily life, including but not limited to
    • Qualitative research describing perceptions of chronic cough and impact on health-related quality of life, work, relationships, etc.
    • Quantitative surveys describing what patients consider clinically relevant improvements in cough outcomes, including valuations of cough frequency, severity, PRO’s or other relevant outcomes
  • Studies in human to evaluate the pathophysiological mechanisms of chronic cough, including cough challenge responses to chemical and to normal physiologic and environmental stimuli such as talking, laughing, exercise, air temperature and others.
    • What are the differences between normal controls and patients with CC
    • Characterization of airway inflammation in patients with CC (including allergic and non-allergic components)
  • Pre-clinical mechanistic studies to characterize
    • ATP release and its role in cough (i.e. cells that release ATP, factors that result in release, biochemical pathways)
    • The role of the P2X3 receptor in animal models of cough
  • Development and/or evaluation of practical cough management tools (i.e. Cough Control Test; Punum ladder, other) aimed to support medical care and follow-up of chronic cough patients

Please complete a full protocol and detailed budget via Visiontracker, the Company's on-line study management system (in US) or your MSD country representative (outside US). The proposals will be collectively reviewed and selected by the Cough MISP Committee.


MISP Information
This site is intended for US investigators only. Investigators outside of the US interested in submitting research proposals to the Investigator Studies Program should contact their local MSD office.