Investigator Studies Program (MISP): Contraception
Effective November 2018, the Contraception Investigator Studies Program (MISP) Committee will accept proposals within our current areas of interest (AOI). This is a competitive process that will be conducted by the Contraception MISP in 2019. Decisions will be made based on scientific merit and strategic fit within the AOI.

The following areas are of interest to Investigator Studies Program Committee:
  • Pro- or retrospective observational studies evaluating the use of Nexplanon/LARCs in adolescent gynecology and primary care settings.
    • Outcomes:
      • specific counseling requirements and effectiveness of counseling
      • uptake of Nexplanon/LARCs vs other contraceptive methods
      • continuation rates and (repeat) pregnancy prevention, cost effectiveness
      • potential hurdles/barriers
  • Prospective or retrospective observational studies evaluating the impact of interventions that reduce barriers to the utilization of Nexplanon / LARCs within clinics and networks.
    • Outcomes:
      • uptake of Nexplanon/LARCs,
      • implant continuation and pregnancy prevention,
      • health economics, and/or
      • impact on achieving educational/professional goals.
  • Prospective or retrospective observational studies evaluating the impact of interventions that remove barriers preventing women from having Nexplanon / LARCs inserted the same day that the patient selected method is prescribed.
    • Interventions focusing on:
      • inability for clinic to stock;
      • requirements for pharmacy dispensing or additional approvals
      • other reasons.
    • Outcomes:
      • uptake of Nexplanon/LARCs, continuation rates.
  • Studies investigating the impact of national, regional, local or hospital policy and/or reimbursement changes affecting LARC/ENG implants and other contraceptives.
    • Outcomes:
      • changes in access to and uptake of LARC/ENG implants and other contraceptives, continuation of methods, pregnancy prevention,
      • health economics consequences, and
      • impact on achieving educational/professional goals.
  • Studies investigating the bleeding pattern of etonogestrel (ENG) implants including
    • evaluating new interventions to reduce frequent/prolonged bleeding while using the ENG implant
    • evaluating the impact of counselling on satisfaction and continuation of the ENG implant
  • Studies evaluating non-contraceptive therapeutic effects of the ENG implant.
  • Studies investigating drug interactions between the ENG implant and new anti-epileptics or anti-retrovirals.

Please complete a full protocol and detailed budget via Visiontracker, the Company's on-line study management system (in US) or your MSD country representative (outside US). The proposals will be collectively reviewed and selected by the Contraception MISP Committee.


MISP Information
This site is intended for US investigators only. Investigators outside of the US interested in submitting research proposals to the Investigator Studies Program should contact their local MSD office.