Investigator Studies Program (MISP): Non-Alcoholic SteatoHepatitis (NASH)
Effective January 2020, the NASH Investigator Studies Program (ISP) Committee will accept proposals within our current areas of interest (AOI) up to February 20, 2020 for the first review cycle, up to June 10, 2020 for the second review cycle and up to October 8, 2020 for the third review cycle. This is a competitive process; decisions will be made on the basis of scientific merit and strategic fit within the AOI.

The following areas are of interest to the Investigator Studies Program Committee:

Mechanism of action and disease biology
  • Effects of activation of FGF receptors relevant to non-alcoholic fatty liver disease (NAFLD), including non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH); differentiation of selective FGFR1c vs non-selective FGF receptor (including FGFR4) activation
  • Mechanism of action of beta-klotho/FGFR1c activation regarding the reduction of liver fat
  • Link between liver fat reduction and improvement of NASH; quantitative and mechanistic relationship between liver fat and disease activity and fibrosis
  • Targets/MOAs/treatment modalities that are additive or synergistic in combination with beta-klotho/FGFR1c activation for liver fat reduction and/or the treatment of NASH
  • Molecular mechanisms responsible for the progression from NAFL to NASH and from NASH to liver cirrhosis
  • Mechanistic link between NAFLD/NASH and CVD

Biomarkers
  • Non-invasive biomarkers for the diagnosis of NASH
  • Predictive biomarkers for NASH progression
  • Predictive biomarkers for the treatment response to beta-klotho/FGFR1c activation

Epidemiology
  • Influence of geographic and racial/ethnic differences as well as genetic and environmental/acquired factors on progression of NAFL and NASH
  • NAFLD/NASH disease burden in different regions

Please complete a full protocol and detailed budget via Visiontracker, the Company's on-line study management system (in US) or your MSD country representative (outside US). The proposals will be collectively reviewed and selected by the NASH MISP Committee.



MISP Information
This site is intended for US investigators only. Investigators outside of the US interested in submitting research proposals to the Investigator Studies Program should contact their local MSD office.