Investigator Studies Program (MISP): Antimicrobial Stewardship
Effective January 2019, the Antimicrobial Stewardship Investigator Studies Program (MISP) Committee will accept proposals within our current areas of interest (AOI) up to May 8, 2019. This is a competitive process that will be conducted by the Antimicrobial Stewardship MISP in 2019. Decisions will be made on the basis of scientific merit and strategic fit within the AOI. Please review the critical activities and abide by the timelines as outlined below.

The following areas are of interest to Investigator Studies Program Committee:
  • Evaluation of the most effective strategies for antimicrobial stewardship (AS), including infection prevention, in alternative settings, transitions of care, and/or special/vulnerable populations
  • Integration of ASPs across integrated delivery networks (IDNs), accountable care organizations (ACOs), or ASP practices in regions with unmet need
  • Identifying risk factors/drivers for inappropriate or ineffective antimicrobial use decisions and/or variability in antimicrobial prescribing across prescribers and regions and evaluation of strategies to improve such decision making/increase consistency with evidence-based practices
  • Use of clinical decision support within electronic medical records and/or telemedicine for ASPs
  • Use of approved rapid diagnostics and/or other diagnostic stewardship devices for ASPs
  • Behavioral and implementation sciences relative to the conduct of ASPs
  • Evaluation of the impact of ASP intervention(s) on outcomes that may include, but are not limited to, the following:
    • Patient outcomes (e.g. length of stay, readmission, mortality)
    • Unintended consequences of antibiotic use (e.g. toxicity, resistance, selection of pathogenic organisms, effects on microbiome)
    • Process measures (e.g. appropriateness of antimicrobial use, time to active/appropriate therapy, guideline adherence)
  • Assessing antimicrobial resistance trends, the evolution of those trends, and ASP decision making.

Please complete a full protocol and detailed budget via Visiontracker, the Company's on-line study management system (in US) or your MSD country representative (outside US). The proposals will be collectively reviewed and selected by the Antimicrobial Stewardship MISP Committee.

Critical Activities and Timelines:
Activity 1st Review Cycle
Full Protocol Submission with Detailed Budget May 8, 2019
MISP-RC Review Meeting June 4, 2019


MISP Information
This site is intended for US investigators only. Investigators outside of the US interested in submitting research proposals to the Investigator Studies Program should contact their local MSD office.